 | | DRUG: Hydrocortisone | |
| Entry |
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| Name |
Hydrocortisone (JP18/USP/INN);
HC;
Acticort (TN);
Anusol HC (TN);
Colocort (TN);
Cortef (TN);
Hytone (TN);
Plenadren (TN) |
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| Product |
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| Generic |
ALA-SCALP (Derm Ventures LLC), ALACORT (Crown Laboratories), ANUSOL (Salix Pharmaceuticals), HYDROCORTISONE (A-S Medication Solutions), HYDROCORTISONE (A-S Medication Solutions), HYDROCORTISONE (A-S Medication Solutions), HYDROCORTISONE (A-S Medication Solutions), HYDROCORTISONE (A-S Medication Solutions), HYDROCORTISONE (ANI Pharmaceuticals), HYDROCORTISONE (ANI Pharmaceuticals), HYDROCORTISONE (Actavis Pharma), HYDROCORTISONE (Actavis Pharma), HYDROCORTISONE (American Health Packaging), HYDROCORTISONE (Amneal Pharmaceuticals of New York LLC), HYDROCORTISONE (Asclemed USA), HYDROCORTISONE (Asclemed USA), HYDROCORTISONE (Asclemed USA), HYDROCORTISONE (Aurobindo Pharma Limited), HYDROCORTISONE (AvPAK), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Chartwell RX), HYDROCORTISONE (Chartwell RX), HYDROCORTISONE (Crown Laboratories), HYDROCORTISONE (DIRECT RX), HYDROCORTISONE (DIRECT RX), HYDROCORTISONE (E. Fougera & Co. a division of Fougera Pharmaceuticals), HYDROCORTISONE (E. Fougera & Co. a division of Fougera Pharmaceuticals), HYDROCORTISONE (E. Fougera & Co. a division of Fougera Pharmaceuticals), HYDROCORTISONE (E. Fougera & Co. a division of Fougera Pharmaceuticals), HYDROCORTISONE (Greenstone LLC), HYDROCORTISONE (Major Pharmaceuticals), HYDROCORTISONE (NuCare Pharmaceuticals), HYDROCORTISONE (NuCare Pharmaceuticals), HYDROCORTISONE (NuCare Pharmaceuticals), HYDROCORTISONE (NuCare Pharmaceuticals), HYDROCORTISONE (NuCare Pharmaceuticals), HYDROCORTISONE (NuCare Pharmaceuticals), HYDROCORTISONE (PD-Rx Pharmaceuticals), HYDROCORTISONE (Padagis Israel Pharmaceuticals), HYDROCORTISONE (Padagis Israel Pharmaceuticals), HYDROCORTISONE (Preferred Pharmaceuticals), HYDROCORTISONE (Preferred Pharmaceuticals), HYDROCORTISONE (Preferred Pharmaceuticals), HYDROCORTISONE (Preferred Pharmaceuticals), HYDROCORTISONE (Preferred Pharmaceuticals), HYDROCORTISONE (Proficient Rx LP), HYDROCORTISONE (Proficient Rx LP), HYDROCORTISONE (REMEDYREPACK), HYDROCORTISONE (RPK Pharmaceuticals), HYDROCORTISONE (RPK Pharmaceuticals), HYDROCORTISONE (RPK Pharmaceuticals), HYDROCORTISONE (RPK Pharmaceuticals), HYDROCORTISONE (RPK Pharmaceuticals), HYDROCORTISONE (Strides Pharma Science Limited), HYDROCORTISONE (Strides Pharma), HYDROCORTISONE (Taro Pharmaceuticals U.S.A.), HYDROCORTISONE RECTAL SUSPENSION (RETENTION) (Chartwell RX LLC), PROCTO-MED HC (Leading Pharma), PROCTO-MED HC (NuCare Pharmaceuticals), PROCTOCORT (Salix Pharmaceuticals), PROCTOSOL-HC (Bryant Ranch Prepack), PROCTOSOL-HC (Sun Pharmaceutical Industries), PROCTOZONE-HC (Bryant Ranch Prepack), PROCTOZONE-HC (Bryant Ranch Prepack), PROCTOZONE-HC (Bryant Ranch Prepack), PROCTOZONE-HC (NuCare Pharmaceuticals), PROCTOZONE-HC (Preferred Pharmaceuticals), PROCTOZONE-HC (Rising Pharma Holdings), TEXACORT (Mission Pharmacal Company) |
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| Formula |
C21H30O5
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| Exact mass |
362.2093
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| Mol weight |
362.4599
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| Structure |
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| Simcomp |
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| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Dermatological agent
DG03243 Atopic dermatitis agent
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
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| Remark |
| Therapeutic category: | 2452 |
| Product (DG00012): | D00088<JP/US> D00165<US> D00977<JP> D00978<JP/US> D01619<JP/US> D01886<JP/US> D02288<US> |
| Product (mixture): | D04699<JP> D04776<JP> D04801<JP> D08827<JP> D08828<JP> D11582<US> D11627<US> D11855<US> D12134<US> |
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| Efficacy |
Anti-inflammatory, Glucocorticoid receptor agonist |
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| Disease |
Ulcerative colitis [DS: H01466] Primary or secondary adrenocortical insufficiency [DS: H01598] Psoriatic arthritis [DS: H01507] Rheumatoid arthritis [DS: H00630] Juvenile rheumatoid arthritis [DS: H01672] Ankylosing spondylitis [DS: H01674] Acute gouty arthritis [DS: H01532] Systemic lupus erythematosus [DS: H00080] Pemphigus [DS: H01648] Severe erythema multiforme [DS: H01695] Stevens-Johnson syndrome [DS: H01694] Mycosis fungoides [DS: H01463] Psoriasis [DS: H01656] Seborrheic dermatitis [DS: H01652] Seasonal or perennial allergic rhinitis [DS: H01360] Bronchial asthma [DS: H00079] Contact dermatitis [DS: H01357] Atopic dermatitis [DS: H01358] Herpes zoster ophthalmicus [DS: H00366] Optic neuritis [DS: H01717] Pulmonary tuberculosis [DS: H00342] Acquired (autoimmune) hemolytic anemia [DS: H01585] Nephrotic syndrome [DS: H01657] Ulcerative colitis [DS: H01466] Multiple sclerosis [DS: H01490] |
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Metabolism |
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| Interaction |
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| Structure map |
| map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A01 STOMATOLOGICAL PREPARATIONS
A01A STOMATOLOGICAL PREPARATIONS
A01AC Corticosteroids for local oral treatment
A01AC03 Hydrocortisone
D00088 Hydrocortisone (JP18/USP/INN) <JP/US>
A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
A07E INTESTINAL ANTIINFLAMMATORY AGENTS
A07EA Corticosteroids acting locally
A07EA02 Hydrocortisone
D00088 Hydrocortisone (JP18/USP/INN) <JP/US>
C CARDIOVASCULAR SYSTEM
C05 VASOPROTECTIVES
C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
C05AA Corticosteroids
C05AA01 Hydrocortisone
D00088 Hydrocortisone (JP18/USP/INN) <JP/US>
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AA Corticosteroids, weak (group I)
D07AA02 Hydrocortisone
D00088 Hydrocortisone (JP18/USP/INN) <JP/US>
D07X CORTICOSTEROIDS, OTHER COMBINATIONS
D07XA Corticosteroids, weak, other combinations
D07XA01 Hydrocortisone
D00088 Hydrocortisone (JP18/USP/INN) <JP/US>
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H02 CORTICOSTEROIDS FOR SYSTEMIC USE
H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
H02AB Glucocorticoids
H02AB09 Hydrocortisone
D00088 Hydrocortisone (JP18/USP/INN) <JP/US>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BA Corticosteroids, plain
S01BA02 Hydrocortisone
D00088 Hydrocortisone (JP18/USP/INN) <JP/US>
S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
S01CB Corticosteroids/antiinfectives/mydriatics in combination
S01CB03 Hydrocortisone
D00088 Hydrocortisone (JP18/USP/INN) <JP/US>
S02 OTOLOGICALS
S02B CORTICOSTEROIDS
S02BA Corticosteroids
S02BA01 Hydrocortisone
D00088 Hydrocortisone (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Dermatological Agents
Dermatitis and Pruitus Agents
Glucocorticoids, Low Potency
Hydrocortisone
D00088 Hydrocortisone (JP18/USP/INN)
Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
Hydrocortisone
D00088 Hydrocortisone (JP18/USP/INN)
Inflammatory Bowel Disease Agents
Glucocorticoids
Hydrocortisone
D00088 Hydrocortisone (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
24 Hormones
245 Adrenal hormone preparations
2452 Cortisones
D00088 Hydrocortisone (JP18/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
Agents for integumentary system
57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
D00088 Hydrocortisone (JP18/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
Designated second-class OTC drugs
Inorganic and organic chemicals
Hydrocortisone
D00088 Hydrocortisone (JP18/USP/INN)
Second-class OTC drugs
Inorganic and organic chemicals
Hydrocortisone
D00088 Hydrocortisone (JP18/USP/INN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00012 Hydrocortisone
D00088 Hydrocortisone
Dermatological agent
DG03243 Atopic dermatitis agent
D00088 Hydrocortisone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00012 Hydrocortisone
D00088 Hydrocortisone
Drug classes [BR:br08332]
Anti-inflammatory
DG01955 Corticosteroid
D00088 Hydrocortisone
Dermatological agent
DG03243 Atopic dermatitis agent
D00088 Hydrocortisone
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D00088 Hydrocortisone (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00088 Hydrocortisone
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D00088
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00088
Topical steroids potency [br08317.html]
Classification in the USA
D00088
Rx-to-OTC switch list in the USA [br08315.html]
D00088
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00012 Hydrocortisone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00012 Hydrocortisone
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| Other DBs |
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| KCF data |
ATOM 26
1 C1y C 25.3915 -16.8055
2 C1y C 24.2081 -17.4875
3 C1z C 25.3915 -15.4414
4 C1x C 27.7583 -16.8055
5 C1y C 23.0247 -16.8055
6 C1x C 24.1965 -18.8575
7 C1z C 26.5809 -14.7535
8 C1x C 24.2081 -14.7535
9 C1a C 25.3858 -14.0713
10 C1x C 27.7583 -15.4414
11 C1z C 21.8356 -17.4875
12 C1y C 23.0247 -15.4414
13 C1x C 23.0247 -19.5395
14 C5a C 26.5866 -13.3893
15 C2y C 21.8356 -18.8575
16 C1x C 20.6579 -16.8055
17 C1a C 21.8239 -16.1233
18 O1a O 21.8356 -14.7535
19 C1b C 27.7643 -12.7072
20 O5a O 25.3975 -12.7072
21 C2x C 20.6579 -19.5395
22 C1x C 19.4687 -17.4875
23 O1a O 28.9534 -13.3951
24 C5x C 19.4687 -18.8575
25 O5x O 18.2853 -19.5395
26 O1a O 27.9332 -14.3911
BOND 29
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 1
7 3 8 1
8 3 9 1 #Up
9 4 10 1
10 5 11 1
11 5 12 1
12 6 13 1
13 7 14 1 #Up
14 11 15 1
15 11 16 1
16 11 17 1 #Up
17 12 18 1 #Up
18 14 19 1
19 14 20 2
20 15 21 2
21 16 22 1
22 19 23 1
23 21 24 1
24 24 25 2
25 7 10 1
26 8 12 1
27 13 15 1
28 22 24 1
29 7 26 1 #Down
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